Voxel-wise correlation of positron emission tomography/computed tomography with multiparametric magnetic resonance imaging and histology of the prostate using a sophisticated registration framework

HM Reynolds; S Williams; P Jackson; C Mitchell; MS Hofman; RJ Hicks; DG Murphy; A Haworth

Journal article

Voxel-wise correlation of positron emission tomography/computed tomography with multiparametric magnetic resonance imaging and histology of the prostate using a sophisticated registration framework

HM Reynolds, S Williams, P Jackson, C Mitchell, MS Hofman, RJ Hicks, DG Murphy, A Haworth

BJU International | WILEY | Published : 2019

DOI: 10.1111/bju.14648

Download PDF

Abstract

Objectives: To develop a registration framework for correlating positron emission tomography/computed tomography (PET/CT) images with multiparametric magnetic resonance imaging (mpMRI) and histology of the prostate, thereby enabling voxel-wise analysis of imaging parameters. Patients and Methods: In this prospective proof-of-concept study, nine patients scheduled for radical prostatectomy underwent mpMRI and PET/CT imaging before surgery. One had PET imaging using 18F-fluoromethylcholine, five using 68Ga-labelled prostate-specific membrane antigen (PSMA)-HBED-CC (PMSA-11), and three using a trial 68Ga-labelled THP-PSMA tracer. PET/CT data were co-registered with mpMRI via the CT scan and an ..

View full abstract

University of Melbourne Researchers

Catherine Mitchell Author

Declan Murphy Author

Related Projects (1)

BIOFOCUSSED PROSTATE CANCER RADIOTHERAPY (BIRT): A PERSONALISED APPROACH TO DELIVERING THE RIGHT DOSE TO THE RIGHT PLACE

We propose a new approach to treating prostate cancer with radiotherapy to move from the standard whole prostate treatment to a personalised..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Dr Reynolds is funded by a Movember Young Investigator Grant through the Prostate Cancer Foundation of Australia's (PCFA) Research Programme. This study is supported by the National Health and Medical Research Council (NHMRC) grant 1126955 and a Priority-driven Collaborative Cancer Research Scheme (PdCCRS) grant 628592 with funding partners: PCFA, and the Radiation Oncology Sectionof the Australian Government Department of Health and Aging and Cancer Australia. Professor Hofman is supported by a Clinical Fellowship Award from the Peter MacCallum Foundation and a Movember Clinical Trials Award awarded through the PCFA's Research Programme. Professor Hicks is supported by a NHMRC Practitioner Fellowship grant. The authors would like to thank Courtney Savill and Lauren Caspersz for their contribution to specimen preparation and MRI acquisition, respectively.